Internal Medicine Research – Open Journal (ISSN: 2771-800X)

Internal Medicine Research – Open Journal (ISSN: 2771-800X)

Internal Medicine Research – Open Journal, is an International, online journal to expedite rapid publication and to introduce unique innovations and discoveries in basic and clinical sciences of Internal medicine. It was founded by a group of scientists for medical research and clinical scholarly doctors from around the world, who are devoted to the promotion and advancement of our understanding of the diseases and their treatments. The journal essences on advancing therapeutic sciences produced from basic sciences, clinical, and research group or general well being exploration to coordinate looks into in all parts of human well being. In this regard the journal publishes unique & inventive scientific articles, editorials, discussions, advancements, current innovations in internal medicine and other information relevant to internal medicine and related fields.

The scope of the journal includes clinical medicine, epidemiology, prevention, health care delivery, curriculum development, internal medicine, cardiology, clinical immunology, clinical pharmacology, endocrinology, gastroenterology, geriatrics, haematology, contagious diseases, oncology, nephrology, neurology, nuclear medicine, palliative medicine, respiratory medicine and rheumatology.

You are welcome to submit your work to submissions@researchopenworld.com

Open Access Policy: This journal is an open access journal which provides immediate, worldwide, boundary free access to the full content of every distributed article without charging readers or their institutions for access. Readers are given authorization to read, circulate, copy, print, download, search, or link to the full texts of all articles in IMROJ.

Editorial Board

Editors In Chief

Prof. Giuseppe Murdaca, Ph.D.
Expertise in Immunology,
Department of Internal Medicine,
University of Genova,
ITALY

Adel Ekladious
Senior consultant and Professor of Medicine
Bunbury Regional Hospital
University of Western Australia
Australia

Dr.Amr Edrees, M.D.

Specialization in Rheumatology,
Internal Medicine,University of Missouri,
Kansas City,
USA


Prof. Federico Cacciapuoti

Department of Internal Medicine,
Faculty of Medicine,
Second University of Naples,Naples,
ITALY


Dr.Francesco Bellanti

Hepatology,
Internal Medicine (General Medicine),
University of Foggia,Foggia,
ITALY


Dr.Burak Uz, MD

Gazi University Faculty of Medicine,
Department of Internal Medicine,
Division of Adult Hematology, Ankara,
Turkey


Dr.Gaurav K.Sharma, MD

The Department of Internal Medicine,
Mercy Hospital and Medical Center,
Chicago,
USA


Dr.Chaddha Ashish

Department of Internal Medicine,
University of Wisconsin Hospital and Clinics,Madison,
USA


Prof. Monica Lamberti

Second University of Naples,
Caserta,
Campania,
ITALY


Dr.Rahul Vasudev, Ph.D.

New York Medical college,
St Joseph’s Regional Medical Center,
New Jersey,
USA


Prof. Yoshitaka Fukuzawa

Professor and Director,
Preemptive and Integrative Medicine Center,
Aichi Medical University &
Aichi Medical Hospital,
Japan

Prof. Chung-Yi Chen

Dean and Professor,
School of Medical and Health Sciences,
Fooyin University, Taiwan,
CHINA


Dr.Fadi Haddad

Department of Internal Medicine,
Staten Island University Hospital/Northwell Health,Staten Island,NY,
USA


Prof. Massimo Ciccozzi

International Education, Didactics, Adult Education,
Department of Infectious Diseases,
Italian National Institute of Health, Rome,
ITALY


Dr.Luigi Pagliaro

Professor Emeritus of Internal Medicine,
University of Palermo,
Palermo,
ITALY


Dr.Mahir Cengiz ,MD

Internal Medicine
(General Medicine),
University of Istanbul,Istanbul,
Turkey


Dr.Shadi Hamdeh

Creighton University School of Medicine,
Department of Internal Medicine,
Omaha, NE,
USA


Dr.Sumru Savas

Ege University,
Department of Internal Medicine,
Section of Geriatrics,Izmir,
Turkey


Dr.Katherine S Blondon, Ph.D.

Division of General Internal Medicine,
Geneva University Hospitals,
Geneva,
Switzerland

Dr.Wei-Gang Hu

Bio-Threat Defence Section,
Defence Research & Development Canada,
Suffield Research Centre,
Canada


Dr.Theodosios Filippatos ,MD,PHD

Department of Internal Medicine,
School of Medicine,
University of Loannina,Loannina,
Greece


Dr.Moses Elisaf

Professor of Medicine,
Director of the Second Department of Internal Medicine,University of Ioannina,
Greece


Dr.Nilay Patel

Internal Medicine Department,
Saint Peter’s University Hospital,
New Brunswick,NJ,
USA


Dr.Antonio Simone Laganà, M.D.

Unit of Gynecology and Obstetrics,
Department of Human Pathology in Adulthood and Childhood “G. Barresi”,University of Messina,
ITALY


Dr.Leonardo Roever

Department of Clinical Research,
Federal University of Uberlandia(UFU),
Uberlandia,
Brazil


Prof. Essam Ahmed Al-Moraissi

Department of Oral and Maxillofacial Surgery,
Faculty of Dentistry,
Thamar University,
Republic of Yemen


Dr.ITIR Yegenaga

Department of Internal Medicine,
Kocaeli University Medical School,
Kocaeli,
Turkey

Published Articles

Metformin Use and Mortality among Prostate Cancer Patients

Huan-ju Shih, Hua Min, Janusz Wojusaik and Panagiota Kitsantas

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021654

Inguinal Hernias Repair by Laparascopy (TEP)

Olga Caridad León González, Pedro Rolando López Rodríguez, Lais Angélica Ceruto Ortiz, Jorge Agustín Satorre Rocha, Eduardo García Castillo, et al.

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021653

Alcohol and Health: Social Evolution, Production and Control

Paul Durrington and Handrean Soran

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021652

Revision of Sex Hormone Replacement Therapy for CKD Pediatric Cases

Davoud Amirkashani MD and Sedigheh Madani MD

Letter to the Editor – Internal Med Res Open J

From Evolutionary Medicine to Precision Medicine in the Hypertension Treatment in Africa

Ângela Inácio, Laura Aguiar and Manuel Bicho

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021651

Effects of Radiation on Mitochondrial Defective Lymphoblastoid Cells

Jessica Chen, Deepa Sridharan, Chad Cross and Janice Pluth

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021643

How are Vitamin B12 and S-Adenosylmethionine Related?

Perry Allen Frey

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021642

Ovarian Cystadenocarcinoma with an Osteosarcoma Component

Pr S Sakhri esp Boulhart

Case Report – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021641

The Impact of Culture and Beliefs in Cancer Care: Turkish Experience

Sedat Ozkan

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021616

The Organization of the Dental Service in the Voronezh Region

Antonenkov Yu E

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021613

Double-Blind Testing of the Lifewave X39 Patch to Determine GHK-Cu Production Levels

Caitlin A Connor, Melinda H Connor, David Yue, Jens Eickhoff, Susan Wagner and Amy Chang

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021612

Tissue Infiltration of Tumor-Associated Macrophages: Towards the Identification of Therapeutic Targets

Thibaut Sanchez, Frédéric Lagarrigue and Véronique Le Cabec

Short Commentary – Internal Med Res Open J

DOI: 10.31038/IMROJ.2021611

A Safety Signal’s Significance with the COVID-19 Coronavirus

Thomas W Miller

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2020544

Metabolomic Analysis Unfolds Connection of Obesity and Endometrial Cancer

Valentina L. Kouznetsova, Kevin Q. Wang, Benjamin K. Pham and Igor F. Tsigelny

Research Article – Internal Med Res Open J

Personalized and Precision Medicine (PPM) as a Unique Healthcare Model of the Future to Come: Hype or Hope?

Мaria Studneva, Anton Yuryev, Veronica Medvedeva, Hiroyuki Abe, Elena Antonova, Vassiliy Tsytsarev, Trevor Marshall, Andrew D Miller and Sergey Suchkov

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2020542

COVID-19 and Type 1 diabetes in Sweden

Johnny Ludvigsson

Research Article – Internal Med Res Open J

Health Care Provider’s Knowledge on Snakes and Snakebites – A Study in the Three Tongu Districts of the Volta Region, Ghana

Evans Paul Kwame Ameade, Isaac Bonney and Evans Twumasi Boateng

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2020534

Disease, Duration and Death

Narayan Bahadur Basnet

Short CommunicationInternal Med Res Open

DOI: 10.31038/IMROJ.2020533

Personalised Approaches in Treating Early-Stage Hodgkin Lymphoma

Tim Illidge and Elizabeth H Phillips

Editorial CommentaryInternal Med Res Open J

DOI: 10.31038/IMROJ.2020531

In Vitro and Intracellular Activities of Omadacycline against Staphylococcus aureus Isolates

Jacques Dubois, Maïtée Dubois and Jean-Francois Martel

Research ArticleInternal Med Res Open J

DOI: 10.31038/IMROJ.2020524

Obesity and Inflammatory Profile: Is Physical Exercise Able to Reverse This Process? A Mini Review

Tito Cardoso de Almeida Mafra, Christiane Salum Machado Simões, Marcus Vinicius Gomes Cezar Vieira, Lı́via Ribeiro Borges Lazzarotto, et al.

Review Article – Internal Med Res Open J

CoVid-19 its Impact on Healthcare Workers and the Need for Occupational Healthcare Provision

Yuke Tien Fong, Jonathan Lam WY, Chua Yeow Leng and Tay Boon Keng

Review ArticleInternal Med Res Open J

DOI: 10.31038/IMROJ.2020523

An Uncommon Cause of Bilateral Pulmonary Nodules in a Long-Term Smoker

Alameeri Amel, Lane Stephen, Mohammed Nur Mutaz, Loftus Barbara and Hogan Brenden

Case ReportInternal Med Res Open J

DOI: 10.31038/IMROJ.2020512

SARS-Cov2: A Review of this Novel Coronavirus

Dominic Worku and Elliott Worku

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2020511

Malignant Urinary bladder paraganglioma in 12 year old boy

Kushagra Gaurav, Priyank Yadav, Aditi Chopra, Saroj Kanta Mishra and Uday Pratap Singh

Case Report – Internal Med Res Open J

Relationship between polycystic ovarian syndrome (PCOS) and fatty liver disease

Sikandar Hayat Khan, Sohail Aslam, Rahat Shahid, Robina Manzoor, Roomana Anwar and Tariq Chaudhry

Research Article – Internal Med Res Open J

Management of Diabetes Patients across the Peri- Operative Pathway: A Systematic Review

Jennifer Wallace, Shahwar Jiwani, Philemon Gyasi-Antwi, Andrew Meal, Gary G. Adams

Research Article – Internal Med Res Open J

Blood Transfusion Guided by Physiological Markers

Mario A Rodríguez Domínguez, Ana Maria Espinosa-Galindo, Luis Javier Marfil-Rivera and Dionisio Palacios-Ríos

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2019425

Urinary Prothrombin Fragment 1 + 2 as an Endogenous Marker of Venous Thromboembolism

Fredrik Wexels, Walter Jeske, Ola E. Dahl and Jawed Fareed

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2019424

First Case Report of Pancreatitis in Lyme disease

A Baisse, S Parreau, A Abdeh and N Pichon

Case Report – Internal Med Res Open J

DOI: 10.31038/IMROJ.2019423

Thoughts at a White Coat Ceremony

Robert T. Means, Jr.

Perspective Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2019422

Occupational Performance of Children and Adolescents with Mucopolysaccharidosis Using Assistive Technologies

Luana Ramalho Jacob, Ana Paula Correa, Fernanda do Nascimento Maia, Dafne Dain Gandelman Horovitz, Carla Trevisan Martins Ribeiro

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2019421

The Impact of Accountable Care Units on Patient Outcomes

David H. Howard, Susan E. Shapiro, David J. Murphy, Elizabeth C. Overton, Liam Chadwick and Jason M. Stein

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2019414

Expectations and Attitudes Regarding Chronic Pain Control: An Exploration Using Mind Genomics

Gillie Gabay, Attila Gere, Glenn Zemel, Danny Moskowitz, Ran Shifron and Howard Moskowitz

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2019412

Blood Pressure in Healthy Youngsters is modified by Vitamin-D Supplementation

Rune Tønnesen, Kristian Buch, Peter Hambak Hovind, Lars Thorbjørn Jensen and Peter Schwarz

Research Article – Internal Med Res Open J

Admission Potassium / Sodium Ratio Linearly Predicts Mortality Outcome Following an Emergency Medical Admission

Richard Conway, Declan Byrne, Deirdre O’Riordan and Bernard Silke

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2019411

Oral Glucose Tolerance Test with Cooked Rhizomes of Zingiber Officinale (Ginger)

Mohammed Abdul Mannan, Khoshnur Jannat and Mohammed Rahmatullah

Research Article – Internal Med Res Open J

Diagnostic and Prognostic Value of Serum Cyfra 21–1 Levels in Patients with Pancreatic Cancer

Jung Hoon Kim, Young Chul Yoon, Joon Cheol Song, Jeong Won Jang and In Sook Woo

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2018342

The Impact of Type 2 Diabetes on Periodontal Health in Elderly Subjects: Princeps Study

Abrar-Ahmad Zulfiqar, M.D, MSc, Jean Doucet, M.D, Ph.D and Hervé Moizan, Ph.D

Letter to the Editor – Internal Med Res Open J

Maternal Obesity and Risk of Stillbirth: A Population-Based Case Control Study and Investigation of Temporal Trends

David J Chinn, Alison Lowrie, Tahir A Mahmood, Helen M Colhoun and Ian W Campbell

Research Article – Internal Med Res Open J

Global Healthcare Workers Migration: A Human Resource Management Concern

James Ducey and Satesh Bidaisee

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2018335

Cross-sectional Study Investigating Texting and Driving in Grenada, West Indies

James A Ducey, Ryan Malave, Iman Zahedi, Emmanual Keku and Satesh Bidaisee

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2018334

Low levels of HDL-cholesterol and endothelial dysfunction: a systematic review and meta-analysis

Leonardo Roever, MHS, Elmiro Santos Resende, PhD, Angélica Lemos Debs Diniz, PhD, Nilson Penha-Silva, PhD, João Lucas O’Connell, PhD, Fernanda Rodrigues de Souza, PhD, Poliana Rodrigues Alves Duarte, PhD, Paulo Fernando Silva Gomes, MD, Américo José Caixeta Neto, Lívia Maria Ambrósio da Silva, Rosangela de Oliveira Felice, Hugo Ribeiro Zanetti, MSc, Anaisa Silva Roerver-Borges, MD, Fernando César Veloso, MHS, Thiago Montes Fidale, PhD, Antonio Casella-Filho, PhD, Paulo Magno Martins Dourado, PhD, Antonio Carlos Palandri Chagas, MD, PhD, Sadeq Ali-Hasan-Al-Saegh, MD, Paulo Eduardo Ocke Reis, PhD, Rogério de MeloCosta Pinto, PhD, Gustavo B. F. Oliveira, PhD, Álvaro Avezum, PhD, Mansueto Neto, PhD, André Durães, PhD, Rose Mary Ferreira Lisboa da Silva, PhD, Antonio José Grande, PhD, CeliseDenardi, MD, Renato Delascio Lopes MD, PhD, NiteshNerlekar, MD, Shahab Alizadeh, MSc, Adrian V. Hernandez, MD, PhD, Maria Inês da Rosa, MD, PhD, Gary Tse, MD, PhD, Tong Liu, MD, PhD, Giuseppe Biondi-Zoccai, MD, MStat

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2018333

Targeting of the Wnt/β-Catenin Pathway in Chronic Lymphocytic Leukaemia may adversely affect CTLA-4 expression and function

Gary Lynch, Paul Kennedy, Stephen Bergin, Siobhan Glavey, Philip W Murphy, John Quinn, and Philip T Murphy

Short Report – Internal Med Res Open J

DOI: 10.31038/IMROJ.2018311

Serum 25-hydroxyvitamin D and Osteocalcin Levels and Insulin Sensitivity in Young Women

Do Kyeong Song, Hyejin Lee and Yeon-Ah Sung

Research Article – Internal Med Res Open J

Plasma Visfatin is reduced in Subjects with the Metabolic Syndrome and Pre-Diabetes

Brema I, Thabit H, Shah S, Burns N, Gasparro D, Crowley V, Storka A, Wolzt M and Nolan JJ

Research Article – Internal Med Res Open J

Relationship between Breast, Formula and Combination Feeding on Childhood in Italy

A. Arrichiello, F. Frezza, G. Auriemma, R. Palomba, and F. Sarubbi

Research Article – Internal Med Res Open J

Association between Dietary Iodine Consumption and Body Composition in Caucasian Females between the Ages of 18 to 60: The Pioneer Project

Pallavi Panth, Alexis Neal, Nancy DiMarco, and Larry Petterborg

Research Article – Internal Med Res Open J

Infection Trend, Distribution, and Factors Associated with Hepatitis B Virus Infection in Delaware, 2005-2015

Nhiem Viet Luong, Mamadou Diallo, Laura Gannon, Martin Luta and Awele Maduka-Ezeh

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2017232

Surrogate Markers of Liver Fibrosis in Primary Sclerosing Cholangitis (PSC)

Monika Szydlowska-Jakimiuk, Joanna Raszeja-Wyszomirska

Research Articles – Internal Med Res Open J

DOI: 10.31038/IMROJ.2017231

A Cross Sectional Study to Assess the Prevalence of Pancreatic Exocrine Insufficiency among Diabetes Mellitus Patients in Turkey

Kadir Demir, Cetin Karaca, Emel Ahishali, Metban Mastanzade, Selda Celik, Nurdan Gul, Fulya Turker, Filiz Akyuz, Fatih Besisik, and Kubilay Karsidag

Research Article – Internal Med Res Open J

Additive Effect of Oral Insulin and an Oral GLP-1 Agonist on Postprandial Glucose Excursions in a Porcine Model

Miriam Kidron, Yael Greenberg-Shushlav, Roy Eldor and Ehud Arbit

Short Communication – Internal Med Res Open J

Peripheral Tryptophan – Kynurenine Metabolism Associated with Metabolic Syndrome is Different in Parkinson’s and Alzheimer’s Diseases

Gregory Oxenkrug, Marieke van der Hart, Julien Roeser, and Paul Summergrad

Research Article – Internal Med Res Open J

Identification Potency of Clinical Isolates in Aspergillus Species Using MALDI-TOF MS

Norihito Tarumoto, Jun Sakai, Keisuke Sujino, Takuya Maeda, Mayu Ohta, Toshiyuki Yamaguchi, Takashi Murakami, Hideaki Ohno and Shigefumi Maesaki

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2017223

Reaching Beyond Patient-Centered Medical Home Walls: A Mixed-Methods Evaluation of A Community Health Team Intervention

Sklar M, Coleman M, Campbell S, Yeracaris P, Hurwitz D, Hewitt S, Fortin EW and Goldman RE

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2017222

WHR is a Better Predictor of Type 2 DM Among Urban Adults in Jos, North Central, Nigeria

Aniekwensi Ezechukwu C and Fabian H Puepet

Research Article – Internal Med Res Open J

Hormonal Aspects of Post-Traumatic Stress Disorder

Lindsey M VanDyke, L Elisabeth Burton, Ajna Hamidovic, Mark R Burge

Research Article – Internal Med Res Open J

Field Deployment of Loop-Mediated Isothermal Amplification for Centralized Mass-Screening of Asymptomatic Malaria in Zanzibar: A Pre-Elimination Setting

Ulrika Morris, Mwinyi Khamis, Berit Aydin-Schmidt, Ali K Abass, Mwinyi I Msellem, et al.

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2017221

Is Intravenous Iron Treatment a Risk for Infection?

Emilio Fábrega, María José García, Carmen Alonso, Manuel Fernandez-Miera, et al.

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2017214

Humanized Monoclonal Antibodies in Pulmonology: An Integrated Review

Arzu DidemYalcin, Kevser Onbasi, RusenUzun, Felix Herth, Philipp Albert Schnabel

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2017213

Basic Food Safety Practise of Open-Air-Market Vending In The Eastern Highlands Of Papua New Guinea

Johnson Makaen, Tobias Maure and Sauli Bebes

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2017211

Obesity and Kidney Disease: Hidden Consequences of the Epidemic

Csaba P. Kovesdy, Susan Furth and Carmine Zoccali

Research Article – Internal Med Res Open J

H Pylori Infection as Risk Factor for GIT Bleeding in Haemophilic Patients

Noha M El Husseiny, Louis Essac and Mona Al Kassas

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016126

Surgical Reduction of Visceral versus Subcutaneous Fat and Effect on Features of the Metabolic Syndrome

Mahmoud Abdelaal, Carel W le Roux and Neil G Docherty

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016125

Restraint Use in the Management of the Elderly with Dementia in Hospital

Lim SC, Poon WH

Review Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016124

Re-igniting the PE debate

Avinash Aujayeb, Joseph Mackenzie

Case Report – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016123

Evidence-Based Medicine (EBM) and Clinical Practice

Luigi Pagliaro

Editorial – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016122

Developing Nutrition Awareness in First Year Medical Students

Bruckner Geza, Elder William and Sehnert Scott

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016116

Discussing Why Hemochromatosis Is Ignored

Rostern Tembo

Research Article – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016114

Ileum Ulcer Bleeding By Cytomegalovirus Infection In A Colon Cancer Patient

Hui-Chun Chao, Khee-Siang Chan and Wen-Liang Yu

Case Report – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016112

Congenital Hypercoagulable Disorders

Federico Cacciapuoti

Editorial – Internal Med Res Open J

DOI: 10.31038/IMROJ.2016111

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